Journal: Frontiers in Pharmacology

Article Title: CYP2J2 ∗ 7 Genotype Predicts Risk of Chemotherapy-Induced Hematologic Toxicity and Reduced Relative Dose Intensity in Ethiopian Breast Cancer Patients

doi: 10.3389/fphar.2019.00481

Figure Lengend Snippet: Genotype and allele frequencies of candidate drug metabolizing enzymes genes by hematologic toxicities, at the radiotherapy center, Tikur Anbessa specialized hospital, Addis Ababa University, Ethiopia.

Article Snippet: In brief genotyping was performed using TaqMan ® drug metabolism genotyping assay reagents for allelic discrimination (Applied Biosystems Genotyping Assays) with the following ID numbers for each SNP: C__7817765_60 for CYP2B6 ∗ 6 (c.516G4T, rs3745274), C__26201809_30 for CYP3A5 ∗ 3 (c.6986A4G, rs776746), C__25625805_10 for CYP2C9 ∗ 2 (rs1799853), C__27104892_10 for CYP2C9 ∗ 3 (rs1057910), C__25986767_70 for CYP2C19 ∗ 2 (rs4244285), C__27861809_10 for CYP2C19 ∗ 3 (rs4986893), C_9581699_80 for CYP2J2 ∗ 7 (rs890293), C_8890131_30 for POR ∗ 28 (rs1057868), and C__11711730_20 for ABCB1 (rs3842).

Techniques:

Journal: Frontiers in Pharmacology

Article Title: CYP2J2 ∗ 7 Genotype Predicts Risk of Chemotherapy-Induced Hematologic Toxicity and Reduced Relative Dose Intensity in Ethiopian Breast Cancer Patients

doi: 10.3389/fphar.2019.00481

Figure Lengend Snippet: Cox proportional hazard regression results for incidence of grade 3 or 4 hematologic toxicity.

Article Snippet: In brief genotyping was performed using TaqMan ® drug metabolism genotyping assay reagents for allelic discrimination (Applied Biosystems Genotyping Assays) with the following ID numbers for each SNP: C__7817765_60 for CYP2B6 ∗ 6 (c.516G4T, rs3745274), C__26201809_30 for CYP3A5 ∗ 3 (c.6986A4G, rs776746), C__25625805_10 for CYP2C9 ∗ 2 (rs1799853), C__27104892_10 for CYP2C9 ∗ 3 (rs1057910), C__25986767_70 for CYP2C19 ∗ 2 (rs4244285), C__27861809_10 for CYP2C19 ∗ 3 (rs4986893), C_9581699_80 for CYP2J2 ∗ 7 (rs890293), C_8890131_30 for POR ∗ 28 (rs1057868), and C__11711730_20 for ABCB1 (rs3842).

Techniques:

Journal: Journal of Personalized Medicine

Article Title: Precision Medicine into Clinical Practice: A Web-Based Tool Enables Real-Time Pharmacogenetic Assessment of Tailored Treatments in Psychiatric Disorders

doi: 10.3390/jpm11090851

Figure Lengend Snippet: NeuroPGx panel (based on OpenArray™ technology).

Article Snippet: , , *8 , 12711T > C , rs41291556 , C__30634130_30 , c.358T > C , p.Trp120Arg.

Techniques: Variant Assay

Journal: Journal of Personalized Medicine

Article Title: Precision Medicine into Clinical Practice: A Web-Based Tool Enables Real-Time Pharmacogenetic Assessment of Tailored Treatments in Psychiatric Disorders

doi: 10.3390/jpm11090851

Figure Lengend Snippet: Selected drugs and CYP genes associated.

Article Snippet: , , *8 , 12711T > C , rs41291556 , C__30634130_30 , c.358T > C , p.Trp120Arg.

Techniques:

Journal: Journal of Personalized Medicine

Article Title: Precision Medicine into Clinical Practice: A Web-Based Tool Enables Real-Time Pharmacogenetic Assessment of Tailored Treatments in Psychiatric Disorders

doi: 10.3390/jpm11090851

Figure Lengend Snippet: Selected SNPs. Frequency of detectable alleles have been calculated according to population data [ 5 ]. Abbr.: SSA = Sub-Saharan African; AA/AC = African American/Afro-Carribbean; Eur = European; NE = Near Eastern; EA = East Asian; CSA = Central/South Asian; Ame = American; Lat = Latino; Oce = Oceanian; AF = allele frequency.

Article Snippet: , , *8 , 12711T > C , rs41291556 , C__30634130_30 , c.358T > C , p.Trp120Arg.

Techniques:

Journal: Journal of Personalized Medicine

Article Title: Precision Medicine into Clinical Practice: A Web-Based Tool Enables Real-Time Pharmacogenetic Assessment of Tailored Treatments in Psychiatric Disorders

doi: 10.3390/jpm11090851

Figure Lengend Snippet: Comparison between guidelines (CPIC and DPWG) and drug labels (FDA and EMA/AIFA) for pharmacogenetic data. Abbr.: FDA = Food and Drug Administration; EMA = European Medicines Agency; AIFA = Italian Medicines Agency; noRec = no recommendation reported in the guideline; N = no information about CYP phenotypes; Y = the label reports information about CYP phenotypes, with or without suggestion to investigate CYP genotype; NA: not approved.

Article Snippet: , , *8 , 12711T > C , rs41291556 , C__30634130_30 , c.358T > C , p.Trp120Arg.

Techniques: Comparison

Journal: Human mutation

Article Title: Structural variation at the CYP2C locus: Characterization of deletion and duplication alleles

doi: 10.1002/humu.23855

Figure Lengend Snippet: CYP2C gene region copy number variants identified by clinical chromosomal microarray (CMA) testing.

Article Snippet: TaqManTM copy number assays targeting CYP2C19 exon 2 (Hs05148033_cn) and intron 6 (Hs02932336_cn) were employed and signals normalized against the TERT gene (Cat# 4403316; Thermo Fisher, Waltham, MA) , and analysis was performed using the Bio-Rad QX-200 Droplet Digital PCR System (Bio-Rad, Hercules, CA).

Techniques: Microarray, Variant Assay

Journal: Human mutation

Article Title: Structural variation at the CYP2C locus: Characterization of deletion and duplication alleles

doi: 10.1002/humu.23855

Figure Lengend Snippet: CYP2C copy number variant (CNV) confirmation by multiplex ligation-dependent probe amplification (MLPA).

Article Snippet: TaqManTM copy number assays targeting CYP2C19 exon 2 (Hs05148033_cn) and intron 6 (Hs02932336_cn) were employed and signals normalized against the TERT gene (Cat# 4403316; Thermo Fisher, Waltham, MA) , and analysis was performed using the Bio-Rad QX-200 Droplet Digital PCR System (Bio-Rad, Hercules, CA).

Techniques: Variant Assay, Multiplex Assay, Ligation, Amplification

Journal: Human mutation

Article Title: Structural variation at the CYP2C locus: Characterization of deletion and duplication alleles

doi: 10.1002/humu.23855

Figure Lengend Snippet: CYP2C copy number variant (CNV) allele and carrier frequencies.

Article Snippet: TaqManTM copy number assays targeting CYP2C19 exon 2 (Hs05148033_cn) and intron 6 (Hs02932336_cn) were employed and signals normalized against the TERT gene (Cat# 4403316; Thermo Fisher, Waltham, MA) , and analysis was performed using the Bio-Rad QX-200 Droplet Digital PCR System (Bio-Rad, Hercules, CA).

Techniques: Variant Assay

Journal: Human mutation

Article Title: Structural variation at the CYP2C locus: Characterization of deletion and duplication alleles

doi: 10.1002/humu.23855

Figure Lengend Snippet: CYP2C copy number variants (CNVs) identified in the Database of Genomic Variants (DGV), ClinGen, and DECIPHER.

Article Snippet: TaqManTM copy number assays targeting CYP2C19 exon 2 (Hs05148033_cn) and intron 6 (Hs02932336_cn) were employed and signals normalized against the TERT gene (Cat# 4403316; Thermo Fisher, Waltham, MA) , and analysis was performed using the Bio-Rad QX-200 Droplet Digital PCR System (Bio-Rad, Hercules, CA).

Techniques: